Biotinylated Human IL-17C Protein (ILC-HM417B)
Catalog: ILC-HM417B
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| Product Description | Recombinant Biotinylated Human IL-17C Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains His19-Val197. |
Product Background |
Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold. IL‑17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. |
Product Category |
Recombinant Protein |
Target |
IL-17C |
Gene/Protein ID |
Q9P0M4 |
Species |
Human |
Exact Sequence |
His19-Val197 |
| Molecular Weight | The protein has a predicted MW of 22.6 kDa. Due to glycosylation, the protein migrates to 25-28 kDa based on Tris-Bis PAGE result. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Liquid |
| Shipping | Shipped with dry ice. |
| Formulation | Supplied as 0.22 um filtered solution in 50mM MES, 150mM NaCl (pH 6.0). |
| Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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The purity of Biotinylated Human IL-17C is greater than 95% as determined by SEC-HPLC. |
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Biotinylated Human IL-17C on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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